SCHEMBL6204216

SCHEMBL6204216

[CH2]C(OC)(OC)c1cccc(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.42
KIF11 P52732 5/20 0.40
TSHR P16473 1/20 0.40
CHRM3 P20309 1/20 0.39
SCN5A Q14524 3/20 0.38
SCN9A Q15858 3/20 0.38
MAPK1 P28482 2/20 0.36
NPSR1 Q6W5P4 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
CCR6 P51684 2/20 0.36
KCNH2 Q12809 1/20 0.36
RELA Q04206 1/20 0.36
ALDH1A1 P00352 3/20 0.36
MEN1 O00255 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
MAPT P10636 1/20 0.36
CYP2C19 P33261 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27473812 0.79 SCN5A (0.41) CYP19A1KIF11TSHRCHRM3SCN5A
SCHEMBL10841821 0.77 CYP19A1 (0.55) CYP19A1KIF11TSHRCHRM3SCN5A
SCHEMBL3096971 0.77 CYP19A1 (0.42) CYP19A1KIF11TSHRCHRM3SCN5A
SCHEMBL6204840 0.76 CA1 (0.41) KIF11TSHRMAPK1NPSR1ALDH1A1
SCHEMBL6205404 0.76 KIF11 (0.47) KIF11MAPK1ALDH1A1CYP3A4MAPT
SCHEMBL10711149 0.76 CYP19A1 (0.42) CYP19A1KIF11TSHRCHRM3SCN5A
SCHEMBL10918770 0.74 KIF11 (0.40) CYP19A1KIF11TSHRSCN5ASCN9A
SCHEMBL6678970 0.74 CYP19A1 (0.45) CYP19A1KIF11TSHRCHRM3SCN5A
SCHEMBL27981136 0.74 MEN1 (0.50) CYP19A1TSHRMAPK1NPSR1MEN1
SCHEMBL2154443 0.73 CES1 (0.47) TSHRMAPK1ALDH1A1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1506175-A1 N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2005-02-16 EP disclosed
WO-2003097609-A1 N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2003-11-27 WO disclosed