Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201831 | 0.79 | DPP4 (0.35) | TAAR1DPP4LMNAALDH1A1HPGD | |
| SCHEMBL6204256 | 0.79 | TAAR1 (0.41) | PPARGPPARATAAR1DPP4LMNA | |
| SCHEMBL28005766 | 0.78 | TRPA1 (0.44) | PPARGPPARATAAR1DPP4ALDH1A1 | |
| SCHEMBL6204278 | 0.78 | PPARG (0.40) | PPARGPPARATAAR1DPP4ALDH1A1 | |
| SCHEMBL6200983 | 0.74 | TAAR1 (0.46) | PPARGPPARATAAR1LMNAALDH1A1 | |
| SCHEMBL28755681 | 0.71 | IDO1 (0.40) | PPARGPPARATAAR1DPP4LMNA | |
| SCHEMBL18901781 | 0.71 | TAAR1 (0.48) | PPARGPPARATAAR1LMNAALDH1A1 | |
| SCHEMBL28558103 | 0.71 | TAAR1 (0.43) | PPARGPPARATAAR1LMNAALDH1A1 | |
| SCHEMBL15067498 | 0.71 | TAAR1 (0.43) | PPARGPPARATAAR1LMNAALDH1A1 | |
| SCHEMBL6201896 | 0.70 | IDO1 (0.38) | PPARGPPARATAAR1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |