Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206629 | 0.95 | POLB (0.56) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6205974 | 0.90 | POLB (0.57) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6206450 | 0.89 | POLB (0.55) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6204974 | 0.89 | POLB (0.64) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6205372 | 0.88 | POLB (0.55) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6204814 | 0.84 | POLB (0.78) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6205058 | 0.83 | POLB (0.62) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6206874 | 0.80 | POLB (0.63) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6204183 | 0.79 | POLB (0.72) | POLBRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6206717 | 0.79 | POLB (0.54) | POLBRAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177177-B1 | SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2005-02-23 | — | — | EP | claimed |