Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2942056 | 0.92 | IGF1R (0.53) | IGF1R | |
| SCHEMBL6204678 | 0.83 | IGF1R (0.67) | IGF1RNPC1RAB9A | |
| SCHEMBL2941507 | 0.81 | IGF1R (0.51) | IGF1RHDAC1HDAC6KDM4E | |
| SCHEMBL6204684 | 0.81 | SORT1 (0.39) | SORT1NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL2934022 | 0.80 | IGF1R (0.49) | IGF1RNPC1RAB9ASMN1; SMN2HDAC1 | |
| SCHEMBL2943419 | 0.80 | IGF1R (0.55) | IGF1R | |
| SCHEMBL2940677 | 0.80 | IGF1R (0.55) | IGF1R | |
| SCHEMBL2941761 | 0.79 | IGF1R (0.55) | IGF1RALDH1A1 | |
| SCHEMBL2995898 | 0.78 | IGF1R (0.51) | IGF1RALDH1A1 | |
| SCHEMBL2990255 | 0.77 | IGF1R (0.54) | IGF1RNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |