Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.74 |
| ▸ | RAB9A | P51151 | 11/20 | 0.74 |
| ▸ | LMNA | P02545 | 9/20 | 0.74 |
| ▸ | NPC1 | O15118 | 9/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.74 |
| ▸ | HTT | P42858 | 7/20 | 0.74 |
| ▸ | TP53 | P04637 | 4/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.71 |
| ▸ | MAPT | P10636 | 9/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 9/20 | 0.68 |
| ▸ | MEN1 | O00255 | 5/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203816 | 0.85 | MAPT (0.68) | KDM4ERAB9ALMNANPC1HSD17B10 | |
| SCHEMBL6206404 | 0.85 | LMNA (0.71) | KDM4ERAB9ALMNANPC1HSD17B10 | |
| SCHEMBL6204905 | 0.85 | MAPT (0.71) | KDM4ELMNAHSD17B10HTTTP53 | |
| SCHEMBL6275801 | 0.85 | LMNA (0.71) | KDM4ERAB9ALMNANPC1HSD17B10 | |
| SCHEMBL8344591 | 0.84 | LMNA (0.74) | KDM4ERAB9ALMNANPC1HSD17B10 | |
| SCHEMBL6364028 | 0.84 | KDM4E (1.00) | KDM4ERAB9ALMNANPC1HSD17B10 | |
| SCHEMBL8342647 | 0.83 | KDM4E (0.65) | KDM4ERAB9ALMNANPC1HSD17B10 | |
| SCHEMBL13790393 | 0.83 | NPC1 (1.00) | KDM4ERAB9ALMNANPC1HSD17B10 | |
| Hydrochloric Acid SCHEMBL6363785 | 0.82 | KDM4E (0.97) | KDM4ERAB9ALMNANPC1HSD17B10 | |
| SCHEMBL8344682 | 0.82 | MAPT (0.64) | KDM4ERAB9ALMNANPC1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |