Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 3/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | PRKACG | P22612 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205471 | 0.93 | CDK5 (0.40) | CDK5CDK5R1CDK1KDM4EALDH1A1 | |
| SCHEMBL6201043 | 0.90 | CDK1 (0.40) | CDK5CDK5R1CDK1MAPTALDH1A1 | |
| SCHEMBL6204246 | 0.86 | BRAF (0.35) | CDK5CDK5R1CDK2CCNE2CCNE1 | |
| SCHEMBL6204587 | 0.85 | BRAF (0.35) | CDK5CDK5R1CDK2CCNE2CCNE1 | |
| SCHEMBL6205187 | 0.84 | HTR2C (0.42) | CDK5CDK5R1CDK1CDK2CCNE2 | |
| SCHEMBL6202531 | 0.83 | CDK5 (0.46) | CDK5CDK5R1CDK1MAPTTDP1 | |
| SCHEMBL6204529 | 0.82 | CCNE2 (0.44) | CDK5CDK5R1CDK1CDK2CCNE2 | |
| SCHEMBL6203534 | 0.80 | CCNE2 (0.46) | CDK1CDK2CCNE2CCNE1 | |
| SCHEMBL6204534 | 0.79 | CLK1 (0.36) | CDK5CDK5R1CDK1MAPTTDP1 | |
| SCHEMBL3445187 | 0.78 | CDK1 (0.61) | CDK5CDK5R1CDK1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | claimed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | claimed |