Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.51 |
| ▸ | ELANE | P08246 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1356223 | 0.84 | TSHR (0.48) | ESR1KMT2ASMN1; SMN2PTGS2CYP19A1 | |
| SCHEMBL16893834 | 0.80 | ELANE (0.45) | ELANERECQLSMN1; SMN2 | |
| SCHEMBL11449884 | 0.80 | ELANE (0.45) | ELANERECQLSMN1; SMN2CYP19A1 | |
| SCHEMBL27668892 | 0.79 | PTGS2 (0.49) | ESR1ELANERECQLKMT2ASMN1; SMN2 | |
| SCHEMBL6204756 | 0.78 | ELANE (0.52) | ESR1ELANEKMT2ACES2CES1 | |
| SCHEMBL124444 | 0.76 | MAPT (0.48) | ELANEKMT2ASMN1; SMN2 | |
| SCHEMBL6677692 | 0.75 | TP53 (0.42) | ELANERECQLKMT2ASMN1; SMN2CES2 | |
| SCHEMBL1145279 | 0.75 | ELANE (0.51) | ESR1ELANERECQLKMT2ASMN1; SMN2 | |
| SCHEMBL6206060 | 0.75 | TSHR (0.47) | ELANEKMT2ASMN1; SMN2CES2CES1 | |
| SCHEMBL6204948 | 0.75 | ELANE (0.51) | ESR1ELANERECQLKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |