Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.72 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4426833 | 0.92 | CCR2 (0.65) | SIGMAR1TEAD1DRD4 | |
| SCHEMBL4846218 | 0.92 | CCR2 (0.65) | SIGMAR1TEAD1DRD4 | |
| SCHEMBL4426840 | 0.92 | CCR2 (0.65) | SIGMAR1TEAD1DRD4 | |
| SCHEMBL4844753 | 0.87 | SIGMAR1 (0.79) | SIGMAR1POLB | |
| Hydrochloric Acid SCHEMBL31462260 | 0.86 | SIGMAR1 (0.77) | SIGMAR1POLB | |
| SCHEMBL3590338 | 0.84 | SIGMAR1 (0.73) | SIGMAR1TEAD1LMNADRD4POLB | |
| SCHEMBL4214471 | 0.83 | TEAD1 (0.73) | SIGMAR1TEAD1LMNADRD4POLB | |
| SCHEMBL4847367 | 0.82 | CCR2 (0.71) | SIGMAR1DRD4 | |
| SCHEMBL4844836 | 0.82 | CCR2 (0.71) | SIGMAR1DRD4 | |
| SCHEMBL4848447 | 0.81 | CCR2 (0.66) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1553085-A1 | Cyclic amine derivatives and their use as drugs | TEIJIN LIMITED (JP) | 2005-07-13 | — | — | EP | disclosed |
| EP-1535909-A2 | Cyclic amine derivatives and their use as drugs | TEIJIN LIMITED (JP) | 2005-06-01 | — | — | EP | disclosed |
| US-6451842-B1 | Cyclic amine derivatives and their use as drugs | DUPONT PHARMACEUTICALS COMPANY | 2002-09-17 | — | — | US | disclosed |
| US-6410566-B1 | ATHEROSCLEROSIS; ANTIARTHRITIC AGENTS | TEIJIN LIMITED (JP) | 2002-06-25 | — | — | US | disclosed |
| US-6362177-B1 | INHIBITION OF CHEMOKINE BINDING | TEIJIN LIMITED (JP) | 2002-03-26 | — | — | US | disclosed |