Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5585097 | 0.83 | TDP1 (0.41) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL456245 | 0.83 | TDP1 (0.44) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL1173928 | 0.80 | TDP1 (0.41) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL5154337 | 0.79 | KMT2A (0.41) | TDP1KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL831218 | 0.79 | TDP1 (0.37) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL8177418 | 0.78 | POLB (0.42) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL1173501 | 0.78 | TDP1 (0.39) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL1179577 | 0.76 | TDP1 (0.45) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL6958357 | 0.75 | HSD17B10 (0.36) | TDP1KMT2AMEN1GPR35ALDH1A1 | |
| SCHEMBL7136437 | 0.74 | TDP1 (0.46) | TDP1KMT2AMEN1GPR35ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545523-A1 | 3-&-grave;(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES ASP38 MAP KINASE INHIBITORS | Astex Technology Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2005002673-A1 | RAF KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |
| WO-2004004720-A1 | 3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |