Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15640032 | 0.83 | ALDH1A1 (0.50) | TDP1KMT2AMEN1HSD17B10ALDH1A1 | |
| SCHEMBL7136437 | 0.77 | TDP1 (0.46) | TDP1KMT2AMEN1GPR35HSD17B10 | |
| SCHEMBL33832 | 0.77 | TDP1 (0.46) | TDP1KMT2AMEN1GPR35HSD17B10 | |
| SCHEMBL6205052 | 0.76 | TDP1 (0.42) | TDP1KMT2AMEN1GPR35HSD17B10 | |
| SCHEMBL41322 | 0.75 | GPR35 (0.54) | TDP1KMT2AMEN1GPR35HSD17B10 | |
| SCHEMBL1036583 | 0.75 | TDP1 (0.45) | TDP1KMT2AMEN1GPR35HSD17B10 | |
| SCHEMBL7907932 | 0.75 | TDP1 (0.45) | TDP1KMT2AMEN1GPR35HSD17B10 | |
| SCHEMBL2075134 | 0.75 | TDP1 (0.45) | TDP1KMT2AMEN1GPR35HSD17B10 | |
| SCHEMBL8374 | 0.75 | TDP1 (0.54) | TDP1KMT2AMEN1GPR35HSD17B10 | |
| SCHEMBL1179475 | 0.75 | TDP1 (0.45) | TDP1KMT2AMEN1GPR35HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012164572-A1 | SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-12-06 | — | — | WO | claimed |
| US-12030876-B2 | Aryl hydrocarbon receptor (AHR) agonists and uses thereof | Ikena Oncology, Inc. (US) | 2024-07-09 | — | — | US | disclosed |
| CN-117886821-A | Nitrogen-containing condensed ring derivative inhibitor, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-110637015-B | Fanisole X receptor agonist and application thereof | 奥加诺沃公司 | 2024-04-02 | — | — | CN | disclosed |
| US-20230295147-A1 | ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF | ARYL THERAPEUTICS, INC. | 2023-09-21 | — | — | US | disclosed |
| US-11608329-B2 | Aryl hydrocarbon receptor (AHR) agonists and uses thereof | Ikena Oncology, Inc. (US) | 2023-03-21 | — | — | US | disclosed |
| CN-115279741-A | 4-phenyl-N- (phenyl) thiazol-2-amine derivatives and related compounds as Aryl Hydrocarbon Receptor (AHR) agonists for the treatment of, for example, angiogenesis-related disorders or inflammatory disorders | 医肯纳肿瘤学公司 | 2022-11-01 | — | — | CN | disclosed |
| EP-3917907-A1 | MODULATORS OF POTASSIUM ION CHANNELS AND USES THEREOF | Universitá Degli Studi Di Salerno (IT) | 2021-12-08 | — | — | EP | disclosed |
| US-20210230153-A1 | ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF | ARYL THERAPEUTICS, INC. | 2021-07-29 | — | — | US | disclosed |
| CN-113056265-A | Farnesoin X receptor agonists and uses thereof | 梅塔科林公司 | 2021-06-29 | — | — | CN | disclosed |
| CN-1083831-C | Novel tricyclic compounds and pharmaceutical compositions containing them | ASAHI CHEMICAL IND (JP) | 2002-05-01 | — | — | CN | disclosed |
| CN-1295064-A | Novel tricyclic compounds and pharmaceutical compositions containing them | ASAHI CHEMICAL IND (JP) | 2001-05-16 | — | — | CN | disclosed |
| CN-1265651-A | Novel tricyclic compound having saturated ring and pharmaceutical composition thereof | ASAHI CHEMICAL IND (JP) | 2000-09-06 | — | — | CN | disclosed |
| CN-1209119-A | Novel tricyclic compounds and pharmaceutical compositions containing them | ASAHI CHEMICAL IND (JP) | 1999-02-24 | — | — | CN | disclosed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | disclosed |
| EP-0007210-B1 | ESTER DERIVATIVES OF N-TRIFLUORO-ACETYL-N-PHOSPHONOMETHYLGLYCINE AND THE HERBICIDAL USE THEREOF | MONSANTO COMPANY (US) | 1982-06-02 | — | — | EP | disclosed |
| US-4218235-A | POSTEMERGENCE AND PREEMERGENCE | MONSANTO COMPANY (US) | 1980-08-19 | — | — | US | disclosed |
| EP-0007210-A2 | Ester derivatives of N-trifluoro-acetyl-N-phosphonomethylglycine and the herbicidal use thereof | MONSANTO COMPANY (US) | 1980-01-23 | — | — | EP | disclosed |
| US-4059432-A | A 2-SULFONYLOXYETHYL-PHOSPHONIC OR -THIONOPHOSPHONIC ACID DERIVATIVE | MITSUBISHI PETROCHEMICAL CO., LTD. (JA) | 1977-11-22 | — | — | US | disclosed |
| US-4059431-A | A 2-SULFONYLOXYETHYL-PHOSPHONIC OR -THIONOPHOSPHONIC ACID DERIVATIVE | MITSUBISHI PETROCHEMICAL CO., LTD. (JA) | 1977-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11608329-B2 | Aryl hydrocarbon receptor (AHR) agonists and uses thereof | AHR, ARNT, HCAR1 | TDP1 3915/4885KMT2A 1031/4885MEN1 4851/4885 |
| US-12030876-B2 | Aryl hydrocarbon receptor (AHR) agonists and uses thereof | AHR, ARNT, HCAR1 | TDP1 3915/4885KMT2A 1031/4885MEN1 4851/4885 |
| US-20230295147-A1 | ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF | AHR, ARNT, HCAR1 | TDP1 3915/4885KMT2A 1031/4885MEN1 4851/4885 |
| US-20210230153-A1 | ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF | AHR, ARNT, HCAR1 | TDP1 3915/4885KMT2A 1031/4885MEN1 4851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.