Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 2/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.34 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.34 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6426744 | 0.83 | KDM4E (0.33) | ALDH1A1GAASMN1; SMN2NR3C1GSK3A | |
| SCHEMBL16039680 | 0.81 | CCNB2 (0.43) | ALDH1A1GAAHTTHPGDSMN1; SMN2 | |
| SCHEMBL4595705 | 0.81 | CA1 (0.58) | CA1CA2ALDH1A1GAALMNA | |
| SCHEMBL8429714 | 0.79 | ALDH1A1 (0.36) | CA1CA2ALDH1A1GAAHTT | |
| SCHEMBL181586 | 0.77 | ALDH1A1 (0.50) | CA1CA2ALDH1A1GAAHTT | |
| SCHEMBL27754527 | 0.77 | CA1 (0.44) | CA1CA2ALDH1A1GAAHTT | |
| SCHEMBL1253501 | 0.77 | ALDH1A1 (0.50) | CA1CA2ALDH1A1GAAHTT | |
| SCHEMBL29922833 | 0.77 | ALDH1A1 (0.50) | CA1CA2ALDH1A1GAAHTT | |
| SCHEMBL14292801 | 0.77 | CA1 (0.44) | CA1CA2ALDH1A1GAAHTT | |
| SCHEMBL13263976 | 0.77 | TDP1 (0.38) | CA1CA2ALDH1A1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |