Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 3/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 2/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL790660 | 0.82 | SLC6A2 (0.47) | IDO1MEN1KMT2AAGXTTACR1 | |
| SCHEMBL4599464 | 0.81 | IDO1 (0.45) | CNR2SLC6A9SLC6A5IDO1TDO2 | |
| SCHEMBL6205190 | 0.81 | CNR2 (0.48) | CNR2SLC6A9SLC6A5IDO1TDO2 | |
| SCHEMBL6035746 | 0.78 | IDO1 (0.43) | CNR2SLC6A9SLC6A5IDO1TDO2 | |
| SCHEMBL28752767 | 0.73 | HDAC4 (0.41) | CNR2SLC6A9SLC6A5IDO1TDO2 | |
| SCHEMBL8658086 | 0.73 | KMT2A (0.51) | MEN1KMT2APPARGNR4A2MAOB | |
| SCHEMBL27648354 | 0.73 | CNR2 (0.50) | CNR2SLC6A9SLC6A5MEN1KMT2A | |
| SCHEMBL2650837 | 0.72 | IDO1 (0.51) | IDO1TDO2AGXTHCAR2NR4A2 | |
| SCHEMBL2651551 | 0.72 | MRGPRX4 (0.54) | — | |
| SCHEMBL22785928 | 0.72 | CA1 (0.47) | CNR2SLC6A9SLC6A5IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |