Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 14/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21774243 | 0.84 | QPCT (0.63) | QPCTNAMPTRAB9ATP53MAPT | |
| SCHEMBL5265936 | 0.79 | NAMPT (0.66) | QPCTNAMPTRAB9ATP53MAPT | |
| SCHEMBL6625320 | 0.78 | ADRA2A (0.58) | QPCTNAMPTRAB9ATP53MAPT | |
| SCHEMBL19558132 | 0.78 | ADRA2A (0.58) | QPCTNAMPTRAB9ATP53MAPT | |
| SCHEMBL11580425 | 0.77 | QPCT (0.63) | QPCTNAMPTRAB9ATP53MAPT | |
| SCHEMBL1232537 | 0.75 | HDAC6 (0.57) | RAB9AMAPTPRKCI | |
| SCHEMBL29941136 | 0.75 | HDAC6 (0.57) | RAB9AMAPTPRKCI | |
| SCHEMBL5063947 | 0.74 | ADRA2A (0.58) | QPCTNAMPTMAPTADRA2AADRA2C | |
| SCHEMBL16683681 | 0.74 | QPCT (0.77) | QPCTRAB9ANPC1 | |
| SCHEMBL27548486 | 0.74 | NAMPT (0.67) | QPCTNAMPTRAB9ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551842-A1 | PYRADAZINE COMPOUNDS AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004035588-A1 | PYRADAZINE COMPOUNDS AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-29 | — | — | WO | disclosed |