Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 16/20 | 0.61 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203974 | 0.81 | SLC6A2 (0.42) | CCR8SMYD3HDAC8HDAC6SLC6A2 | |
| SCHEMBL1338876 | 0.80 | CCR8 (0.60) | CCR8 | |
| SCHEMBL6409599 | 0.77 | SMYD3 (0.39) | CCR8SMYD3HDAC8HDAC6SLC6A2 | |
| SCHEMBL6248251 | 0.76 | CCR8 (0.57) | CCR8 | |
| SCHEMBL1338154 | 0.76 | CCR8 (1.00) | CCR8 | |
| SCHEMBL6438547 | 0.75 | CCR8 (0.55) | CCR8 | |
| SCHEMBL6204924 | 0.75 | CCR8 (0.55) | CCR8 | |
| SCHEMBL6365514 | 0.75 | CCR8 (0.54) | CCR8 | |
| SCHEMBL6408725 | 0.74 | CCR8 (0.54) | CCR8 | |
| SCHEMBL6364712 | 0.74 | CCR8 (0.54) | CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590327-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1581511-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058709-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004058736-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-07-15 | — | — | WO | disclosed |