Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203974 | 0.84 | SLC6A2 (0.42) | SMYD3L3MBTL1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6205310 | 0.77 | CCR8 (0.61) | SMYD3SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL1339959 | 0.70 | KMT2A (0.53) | CCR8KMT2AHTTSMN1; SMN2MEN1 | |
| SCHEMBL6416674 | 0.69 | CYP1A2 (0.43) | SLC6A2SLC6A4SLC6A3KCNH2CCR8 | |
| SCHEMBL2958329 | 0.67 | CNR2 (0.57) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6205468 | 0.67 | SLC6A4 (0.42) | SLC6A2SLC6A4SLC6A3KCNH2CCR8 | |
| SCHEMBL6365514 | 0.67 | CCR8 (0.54) | CCR8 | |
| SCHEMBL24392681 | 0.66 | SLC6A2 (0.53) | SMYD3SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6204924 | 0.66 | CCR8 (0.55) | CCR8 | |
| SCHEMBL6254437 | 0.66 | CCR8 (0.57) | CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581511-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058736-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-07-15 | — | — | WO | disclosed |