Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6409599 | 0.84 | SMYD3 (0.39) | SLC6A2SLC6A4KCNH2SLC6A3SMYD3 | |
| SCHEMBL6205310 | 0.81 | CCR8 (0.61) | SLC6A2SLC6A4KCNH2SLC6A3SMYD3 | |
| SCHEMBL6205468 | 0.78 | SLC6A4 (0.42) | SLC6A2SLC6A4KCNH2SLC6A3HTR6 | |
| SCHEMBL24392681 | 0.73 | SLC6A2 (0.53) | SLC6A2SLC6A4KCNH2SLC6A3SMYD3 | |
| SCHEMBL6204695 | 0.72 | SLC6A2 (0.40) | SLC6A2SLC6A4KCNH2SLC6A3MEN1 | |
| SCHEMBL4344607 | 0.72 | CCR8 (0.66) | HTR6CCR8NSD2 | |
| SCHEMBL2958329 | 0.72 | CNR2 (0.57) | SLC6A2SLC6A4KCNH2SLC6A3 | |
| SCHEMBL3811903 | 0.69 | DCUN1D1 (0.58) | SLC6A2SLC6A4KCNH2SLC6A3DCUN1D1 | |
| SCHEMBL6204001 | 0.69 | SLC6A4 (0.39) | SLC6A2SLC6A4KCNH2SLC6A3KMT2A | |
| Hydrochloric Acid SCHEMBL21410210 | 0.68 | DCUN1D1 (0.57) | SLC6A2SLC6A4KCNH2SLC6A3DCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590327-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1581511-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058709-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004058736-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-07-15 | — | — | WO | disclosed |