Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34471497 | 0.61 | — | — | |
| SCHEMBL7657168 | 0.57 | — | — | |
| SCHEMBL13359252 | 0.57 | P2RX7 (0.59) | KDM4EL3MBTL1 | |
| SCHEMBL6382380 | 0.56 | P2RX7 (0.38) | HDAC1HDAC6KDM4EL3MBTL1 | |
| SCHEMBL2537422 | 0.56 | — | — | |
| SCHEMBL12424114 | 0.55 | CYP2C9 (0.41) | HDAC1HDAC6L3MBTL1CYP2C9 | |
| SCHEMBL9452549 | 0.55 | CYP2C9 (0.37) | CYP2C9 | |
| SCHEMBL9998298 | 0.55 | GNAI3 (0.40) | KDM4ECYP2C9 | |
| SCHEMBL2534494 | 0.55 | — | — | |
| SCHEMBL1678458 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | Chiron Corporation (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003082272-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | CHIRON CORPORATION (US) | 2003-10-09 | — | — | WO | disclosed |