Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.37 |
| ▸ | CTSL | P07711 | 3/20 | 0.35 |
| ▸ | CTSB | P07858 | 3/20 | 0.35 |
| ▸ | CTSH | P09668 | 2/20 | 0.34 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14240897 | 0.78 | METAP1 (0.43) | METAP2METAP1CYP1A2 | |
| SCHEMBL9205347 | 0.76 | CYP1A2 (0.36) | CTSKCTSLCTSBCTSHCYP1A2 | |
| SCHEMBL20354119 | 0.76 | KDM4E (0.34) | CTSKCTSLCTSBMETAP2METAP1 | |
| SCHEMBL9997991 | 0.75 | THRB (0.31) | — | |
| SCHEMBL14537236 | 0.74 | CTSK (0.45) | CTSKCTSLCTSBCTSHCYP1A2 | |
| SCHEMBL28572126 | 0.74 | CTSK (0.41) | CTSKCTSLCTSBCTSHMETAP2 | |
| SCHEMBL1037969 | 0.73 | CTSK (0.40) | CTSKCTSLCTSBCTSHMEN1 | |
| SCHEMBL16855279 | 0.73 | CTSK (0.40) | CTSKCTSLCTSBCTSHMEN1 | |
| SCHEMBL9819752 | 0.73 | CTSK (0.40) | CTSKCTSLCTSBCTSHMEN1 | |
| SCHEMBL6660560 | 0.73 | CTSK (0.40) | CTSKCTSLCTSBCTSHMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |