Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR2 | P30874 | 6/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205268 | 0.94 | SSTR2 (0.39) | SSTR2CYP2D6CYP2C19MAPK1CYP1A2 | |
| SCHEMBL5706983 | 0.85 | MAPK1 (0.38) | SSTR2CYP2D6CYP2C19MAPK1CYP1A2 | |
| SCHEMBL5707024 | 0.84 | SSTR2 (0.37) | SSTR2CYP2D6CYP2C19MAPK1CYP1A2 | |
| SCHEMBL6246289 | 0.84 | CHEK2 (0.43) | SSTR2CYP2D6CYP2C19CYP1A2SMN1; SMN2 | |
| SCHEMBL6238825 | 0.83 | ESR1 (0.42) | SSTR2CHEK2 | |
| SCHEMBL5420872 | 0.83 | LTA4H (0.51) | LTA4H | |
| SCHEMBL5706374 | 0.82 | SSTR2 (0.35) | SSTR2CYP2D6CYP2C19MAPK1CYP1A2 | |
| SCHEMBL6152202 | 0.79 | LTA4H (0.39) | SSTR2CYP2D6CYP2C19CYP1A2SMN1; SMN2 | |
| SCHEMBL6204189 | 0.79 | CHEK2 (0.44) | SSTR2CYP2D6CYP2C19CYP1A2SMN1; SMN2 | |
| SCHEMBL5426000 | 0.77 | LTA4H (0.47) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551822-A2 | PENTACYCLIC OXEPINES AND DERIVATIVES THEREOF, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009578-A2 | PENTACYCLIC OXEPINES AND DERIVATIVES THEREOF, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 2004-01-29 | — | — | WO | disclosed |