Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288400 | 0.85 | LMNA (0.68) | LMNAGAASMN1; SMN2ATMMEN1 | |
| SCHEMBL31559143 | 0.84 | GAA (0.67) | LMNAGAASMN1; SMN2ATMMEN1 | |
| SCHEMBL31559145 | 0.84 | GAA (0.67) | LMNAGAASMN1; SMN2ATMMEN1 | |
| SCHEMBL6225567 | 0.83 | ATM (0.70) | LMNAGAASMN1; SMN2ATMMEN1 | |
| SCHEMBL1409602 | 0.82 | LMNA (0.65) | LMNAGAASMN1; SMN2ATMMEN1 | |
| SCHEMBL10474169 | 0.82 | LMNA (0.77) | LMNAGAASMN1; SMN2ATMMEN1 | |
| SCHEMBL8251642 | 0.81 | REV1 (0.70) | LMNAGAASMN1; SMN2ATMMEN1 | |
| SCHEMBL12167622 | 0.81 | LMNA (0.90) | LMNAGAASMN1; SMN2ATMMEN1 | |
| SCHEMBL14587230 | 0.80 | ATM (0.63) | LMNAGAASMN1; SMN2ATMMEN1 | |
| SCHEMBL30969294 | 0.80 | POLB (0.70) | LMNAGAASMN1; SMN2ATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |