Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1810243 | 1.00 | ALDH1A1 (0.47) | ALDH1A1ATMPBRM1GPR84NR4A2 | |
| SCHEMBL30410283 | 0.84 | ALDH1A1 (0.45) | ALDH1A1ATMPBRM1GPR84NR4A2 | |
| SCHEMBL18932184 | 0.84 | ALDH1A1 (0.45) | ALDH1A1ATMPBRM1GPR84NR4A2 | |
| SCHEMBL4736469 | 0.84 | ALDH1A1 (0.45) | ALDH1A1ATMPBRM1GPR84NR4A2 | |
| SCHEMBL17866728 | 0.83 | PBRM1 (0.50) | ALDH1A1ATMPBRM1GPR84NR4A2 | |
| SCHEMBL8131871 | 0.83 | NR4A2 (0.51) | ALDH1A1ATMPBRM1GPR84NR4A2 | |
| SCHEMBL6288556 | 0.82 | PBRM1 (0.49) | ALDH1A1ATMPBRM1GPR84NR4A2 | |
| SCHEMBL5172407 | 0.82 | PBRM1 (0.49) | ALDH1A1ATMPBRM1GPR84NR4A2 | |
| SCHEMBL5174863 | 0.82 | PBRM1 (0.49) | ALDH1A1ATMPBRM1GPR84NR4A2 | |
| SCHEMBL29433056 | 0.81 | ALDH1A1 (0.42) | ALDH1A1ATMPBRM1GPR84NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313736-B1 | CONDENSED PYRAZINDIONE DERIVATIVES AS INHIBITORS OF PDE5 | LILLY ICOS LLC (US) | 2005-07-27 | — | — | EP | disclosed |
| US-6903099-B2 | Condensed pyrazindione derivatives | LILLY ICOS LLC (US) | 2005-06-07 | — | — | US | disclosed |
| US-20030181457-A1 | Chemical compounds | LILLY ICOS LLC | 2003-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181457-A1 | Chemical compounds | ABCG2, SDHA, CYP11B1 | ALDH1A1 126/4885ATM 2361/4885PBRM1 2751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.