Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.49 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203871 | 0.78 | ADAM17 (0.68) | ADAM17MMP13MMP2MMP3MMP7 | |
| SCHEMBL1504715 | 0.72 | ADAM17 (0.64) | ADAM17MMP13MMP2MMP3 | |
| SCHEMBL3966497 | 0.71 | ADAM17 (0.60) | ADAM17MMP13MMP2 | |
| SCHEMBL6210176 | 0.70 | ADAM17 (0.55) | ADAM17MMP13MMP2 | |
| SCHEMBL3968177 | 0.70 | ADAM17 (0.61) | ADAM17MMP13MMP2ADAMTS4MMP3 | |
| SCHEMBL1504829 | 0.70 | ADAM17 (0.61) | ADAM17MMP13MMP2MMP3 | |
| SCHEMBL6322111 | 0.70 | ADAM17 (0.73) | ADAM17MMP13MMP2 | |
| SCHEMBL6263430 | 0.70 | MMP13 (0.57) | ADAM17MMP13MMP2ADAMTS4MMP3 | |
| SCHEMBL6321024 | 0.70 | ADAM17 (1.00) | ADAM17MMP13MMP2 | |
| SCHEMBL3964556 | 0.70 | ADAM17 (0.69) | ADAM17MMP13MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551826-A1 | HYDANTOINE DERIVATIVES AND THEIR USE AS TACE INHIBITORS | Astrazeneca AB (SE) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004024721-A1 | HYDANTOIN DERIVATIVES UND DEREN VERWENDUNG ALS TACE INHIBITOREN | ASTRAZENECA AB (SE) | 2004-03-25 | — | — | WO | disclosed |