Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | PHGDH | O43175 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647647 | 1.00 | ALDH1A1 (0.42) | ALDH1A1LMNAACENPC1HTT | |
| SCHEMBL1799002 | 0.82 | ALDH1A1 (0.52) | ALDH1A1LMNAACENPC1HTT | |
| SCHEMBL11831626 | 0.82 | ALDH1A1 (0.52) | ALDH1A1LMNAACENPC1HTT | |
| SCHEMBL646398 | 0.76 | DPP4 (0.40) | ALDH1A1LMNASMN1; SMN2DPP4 | |
| SCHEMBL7135300 | 0.75 | ALDH1A1 (0.51) | ALDH1A1LMNAACESMN1; SMN2GLA | |
| SCHEMBL4177794 | 0.75 | ALDH1A1 (0.51) | ALDH1A1LMNAACESMN1; SMN2GLA | |
| SCHEMBL647869 | 0.75 | DPP4 (0.38) | ALDH1A1SMN1; SMN2DPP4 | |
| SCHEMBL4704107 | 0.75 | DPP4 (0.38) | ALDH1A1SMN1; SMN2DPP4 | |
| SCHEMBL17226166 | 0.71 | RECQL (0.31) | RECQLPHGDHHSD11B1 | |
| SCHEMBL648829 | 0.70 | DPP4 (0.60) | ALDH1A1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560811-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | Abbott Laboratories (US) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004026822-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2004-04-01 | — | — | WO | disclosed |