Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28610752 | 0.80 | CHRM3 (0.36) | MAPTNFKB1NFKB2RELACA12 | |
| Hydrochloric Acid SCHEMBL30655961 | 0.79 | CHRM3 (0.35) | CA12CA1CA2CA9CA14 | |
| SCHEMBL11229915 | 0.75 | NFKB1 (0.39) | TP53MAPTALOX15HSD17B10NFKB1 | |
| SCHEMBL13947269 | 0.73 | TP53 (0.36) | TP53MAPTALOX15HSD17B10NFKB1 | |
| SCHEMBL29152579 | 0.72 | TP53 (0.33) | TP53MAPTALOX15HSD17B10CA12 | |
| SCHEMBL8545778 | 0.71 | TP53 (0.35) | TP53MAPTALOX15HSD17B10NFKB1 | |
| SCHEMBL13947265 | 0.71 | TP53 (0.35) | TP53MAPTALOX15HSD17B10NFKB1 | |
| SCHEMBL604100 | 0.71 | — | — | |
| SCHEMBL29080196 | 0.70 | TP53 (0.34) | TP53MAPTALOX15HSD17B10NFKB1 | |
| SCHEMBL2241122 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565459-A2 | HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS | Pharmacia Corporation (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004048368-A2 | HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2004-06-10 | — | — | WO | disclosed |