Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.62 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1538024 | 0.77 | HTR6 (0.53) | HTR6ALDH1A1MEN1MAPTHTT | |
| SCHEMBL27038476 | 0.76 | HTR6 (0.64) | HTR6HTR2C | |
| SCHEMBL1538256 | 0.75 | HTR6 (0.60) | HTR6 | |
| Hydrochloric Acid SCHEMBL6528932 | 0.70 | HTR6 (0.47) | HTR6HTR2C | |
| SCHEMBL4651322 | 0.70 | HTR2C (0.65) | HTR2CALDH1A1ATMTLR8 | |
| SCHEMBL5758119 | 0.69 | HTR6 (1.00) | HTR6ALDH1A1MEN1HTTKMT2A | |
| SCHEMBL6570590 | 0.69 | HTR6 (0.76) | HTR6MEN1HTTKMT2A | |
| Chlorobenzene SCHEMBL28743159 | 0.68 | HTR6 (0.53) | HTR6HTR2C | |
| Fluorobenzene SCHEMBL28743141 | 0.68 | HTR6 (0.53) | HTR6HTR2C | |
| SCHEMBL24438167 | 0.68 | HTR6 (0.60) | HTR6ALDH1A1MAPTHTTCA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513809-A1 | 1-SULFONYL-4-AMINOALKOXY INDOLE DERIVATIVES AS 5-HT6-RECEPTOR MODULATORS FOR THE TREATMENT OF CNS-DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-16 | — | — | EP | disclosed |
| US-6774241-B2 | HT3 RECEPTOR ANTAGONISTS FOR NERVOUS SYSTEM, PSYCHOLOGICAL, EATING, AND SLEEP DISORDER TREATMENT | ROCHE PALO ALTO LLC | 2004-08-10 | — | — | US | disclosed |
| WO-2003104193-A1 | 1-SULFONYL-4-AMINOALKOXY INDOLE DERIVATIVES AS 5-HT6-RECEPTOR MODULATORS FOR THE TREATMENT OF CNS-DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-12-18 | — | — | WO | disclosed |
| US-20030229069-A1 | 1-Sulfonyl-4-aminoalkoxy indole derivatives and uses thereof | ROCHE PALO ALTO LLC | 2003-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229069-A1 | 1-Sulfonyl-4-aminoalkoxy indole derivatives and uses thereof | IDO1, TPH1, SLC6A4 | HTR6 19/4885HTR2C 36/4885ALDH1A1 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.