Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | BACE1 | P56817 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205560 | 0.94 | POLB (0.58) | POLBBACE1LMNAKDM4EHSD17B10 | |
| SCHEMBL6206709 | 0.90 | POLB (0.70) | POLBLMNAKDM4EHSD17B10L3MBTL1 | |
| SCHEMBL6205644 | 0.84 | POLB (0.55) | POLBBACE1KDM4EHSD17B10NPC1 | |
| SCHEMBL6227484 | 0.83 | POLB (0.81) | POLBBACE1LMNAKDM4EHSD17B10 | |
| SCHEMBL6205917 | 0.83 | ALDH1A1 (0.58) | POLBBACE1HSD17B10NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL6205615 | 0.82 | POLB (0.80) | POLBBACE1LMNAKDM4EHSD17B10 | |
| SCHEMBL6229466 | 0.81 | LMNA (0.69) | POLBBACE1LMNAKDM4EHSD17B10 | |
| SCHEMBL6205412 | 0.81 | ALDH1A1 (0.73) | POLBLMNAKDM4EHSD17B10L3MBTL1 | |
| Hydrochloric Acid SCHEMBL6205976 | 0.81 | LMNA (0.68) | POLBBACE1LMNAKDM4EHSD17B10 | |
| SCHEMBL6229836 | 0.79 | CFTR (0.61) | POLBLMNAL3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177177-B1 | SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2005-02-23 | — | — | EP | claimed |
| US-6413956-B1 | AGONISTS, ANTAGONISTS OR INVERSE AGONISTS AND LOCALIZATION PROBES FOR GAMMA AMINOBUTYRIC ACID BRAIN RECEPTORS; ANXIETY, DEPRESSION, DOWN SYNDROME, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND MEMORY ENHANCEMENT | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| EP-1177177-B1 | SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2005-02-23 | — | — | EP | disclosed |
| US-6413956-B1 | AGONISTS, ANTAGONISTS OR INVERSE AGONISTS AND LOCALIZATION PROBES FOR GAMMA AMINOBUTYRIC ACID BRAIN RECEPTORS; ANXIETY, DEPRESSION, DOWN SYNDROME, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND MEMORY ENHANCEMENT | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |