Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | HPN | P05981 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6072578 | 0.83 | EPHX1 (0.31) | — | |
| SCHEMBL6675008 | 0.83 | PSEN1 (0.32) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4761958 | 0.77 | PSEN1 (0.31) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5770724 | 0.77 | CTSK (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4763307 | 0.77 | PSEN1 (0.32) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6203389 | 0.74 | ALDH1A1 (0.34) | ALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL6609062 | 0.73 | ALDH1A1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7538627 | 0.73 | ALDH1A1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6205921 | 0.72 | PSEN1 (0.30) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5105178 | 0.69 | KCNA5 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539178-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004017911-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |