Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.60 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.60 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.60 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.60 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.60 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.56 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.53 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1098277 | 0.86 | EGLN1 (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL31106173 | 0.86 | EGLN1 (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22283425 | 0.78 | TDP1 (0.71) | KMT2AMAPTKDM4ENPC1RAB9A | |
| SCHEMBL12857691 | 0.78 | KMT2A (0.74) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8773458 | 0.78 | HCRTR1 (0.62) | KMT2AMEN1HCRTR1KDM4EATM | |
| SCHEMBL16562242 | 0.78 | EGLN1 (0.69) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6205790 | 0.76 | HPGD (0.50) | KMT2AMEN1DHODHNPC1RAB9A | |
| SCHEMBL10888080 | 0.76 | PLG (0.66) | ABCG2KMT2AMEN1NPC1RAB9A | |
| SCHEMBL10726702 | 0.76 | TSHR (0.62) | KMT2APOLBHCRTR1KDM4EATM | |
| SCHEMBL244541 | 0.76 | LDHA (0.62) | ABCG2KMT2AMEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938474-B1 | CYCLOPROPYLINDOLE COMPOUNDS AND THEIR USE AS PRODRUGS | AUCKLAND UNISERVICES LTD (NZ) | 2005-11-23 | — | — | EP | disclosed |
| US-6130237-A | Condensed N-aclyindoles as antitumor agents | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-10-10 | — | — | US | disclosed |
| EP-0938474-A2 | CYCLOPROPYLINDOLE COMPOUNDS AND THEIR USE AS PRODRUGS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998011101-A2 | CONDENSED N-ACLYINDOLES AS ANTITUMOR AGENTS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1998-03-19 | — | — | WO | disclosed |