Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA6 | P23280 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | P4HB | P07237 | 5/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206435 | 1.00 | CA12 (0.57) | CA12CA1CA2CA6CA9 | |
| SCHEMBL6205576 | 1.00 | CA12 (0.57) | CA12CA1CA2CA6CA9 | |
| SCHEMBL726746 | 0.80 | ALDH1A1 (0.53) | PARP1NPC1MAPTRAB9AKDM4E | |
| SCHEMBL726429 | 0.80 | CES2 (0.55) | PARP1NPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL726757 | 0.80 | CES2 (0.55) | PARP1NPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL15563146 | 0.80 | PARP1 (0.52) | PARP1NPC1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL15563147 | 0.80 | PARP1 (0.52) | PARP1NPC1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL726747 | 0.80 | ALDH1A1 (0.53) | PARP1NPC1MAPTRAB9AKDM4E | |
| SCHEMBL728344 | 0.80 | ALDH1A1 (0.53) | PARP1NPC1MAPTRAB9AKDM4E | |
| SCHEMBL726756 | 0.80 | CES2 (0.55) | PARP1NPC1SMN1; SMN2RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100763-B1 | DIKETOACID-DERIVATIVES AS INHIBITORS OF POLYMERASES | ANGELETTI P IST RICHERCHE BIO (IT) | 2005-06-22 | — | — | EP | claimed |
| US-9737522-B2 | NMDA receptor modulators and uses related thereto | EMORY UNIVERSITY (US) | 2017-08-22 | — | — | US | disclosed |
| US-20150196540-A1 | NMDA RECEPTOR MODULATORS AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2015-07-16 | — | — | US | disclosed |
| WO-2014025942-A1 | NMDA RECEPTOR MODULATORS AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2014-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150196540-A1 | NMDA RECEPTOR MODULATORS AND USES RELATED THERETO | GRIN2C, GRIN2A, GRIN3A | CA12 2318/4885CA1 735/4885CA2 1595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.