Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.62 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784361 | 0.85 | TACR1 (0.57) | SLC6A2SLC6A3SLC6A4RPS6KB1TACR1 | |
| SCHEMBL7312748 | 0.82 | SLC6A2 (0.68) | SLC6A2SLC6A3SLC6A4SMN1; SMN2MEN1 | |
| SCHEMBL16461973 | 0.81 | RPS6KB1 (0.50) | RPS6KB1KMT2APOLB | |
| SCHEMBL10399500 | 0.80 | SLC6A3 (0.58) | SLC6A2SLC6A3SLC6A4SMN1; SMN2MEN1 | |
| SCHEMBL3669763 | 0.79 | RPS6KB1 (0.49) | RPS6KB1ALDH1A1KMT2APOLB | |
| SCHEMBL5559565 | 0.79 | SLC6A2 (0.45) | SLC6A2SLC6A3SLC6A4TACR1DPP4 | |
| SCHEMBL16461381 | 0.77 | RPS6KB1 (0.50) | SLC6A2SLC6A3SLC6A4RPS6KB1SMN1; SMN2 | |
| SCHEMBL14775283 | 0.77 | SLC6A2 (1.00) | SLC6A2SLC6A3SLC6A4TACR1 | |
| SCHEMBL6231996 | 0.77 | OPRL1 (0.57) | — | |
| SCHEMBL14775500 | 0.76 | SLC6A2 (1.00) | SLC6A2SLC6A3SLC6A4TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709375-B1 | Therapeutic heterocycles | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | EP | disclosed |
| US-6147083-A | NOVEL SUBSTITUTED 1,2-ETHANEDIAMINE DERIVATIVES WHICH ANTAGONIZE THE PHARMACOLOGICAL ACTIONS OF THE ENDOGENOUS NEUROPEPTIDE TACHYKININS KNOWN AS NEUROKININS, USEFUL FOR THE TREATMENT OF ASTHMA, ETC. | ZENECA LIMITED (GB) | 2000-11-14 | — | — | US | disclosed |
| US-5998444-A | ANTIASTHMA AGENTS; NEUROKININ ANTAGONIST | ZENECA LTD. (GB) | 1999-12-07 | — | — | US | disclosed |
| WO-1998017696-A1 | DISPERSANTS AND DISPERSANT VISCOSITY INDEX IMPROVERS FROM SELECTIVELY HYDROGENATED POLYMERS | MOBIL OIL CORPORATION (US) | 1998-04-30 | — | — | WO | disclosed |
| US-5710169-A | NEUROKININ ANTAGONISTS; ANTIHISTAMINES, BRONCHODILATOR AGENTS; ASTHMA | ZENECA LIMITED (GB) | 1998-01-20 | — | — | US | disclosed |
| EP-0709375-A2 | Therapeutic heterocycles | ZENECA LIMITED (GB) | 1996-05-01 | — | — | EP | disclosed |