⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206400 | 0.85 | — | — | |
| SCHEMBL6399021 | 0.83 | CRHR1 (0.33) | — | |
| SCHEMBL6207240 | 0.82 | — | — | |
| SCHEMBL6400380 | 0.82 | FLT1 (0.32) | — | |
| SCHEMBL6207753 | 0.81 | MAP2K2 (0.34) | — | |
| SCHEMBL6400419 | 0.79 | KDM4E (0.38) | — | |
| SCHEMBL6189167 | 0.78 | MAP2K1 (0.42) | — | |
| SCHEMBL6207023 | 0.77 | HTR2A (0.31) | — | |
| SCHEMBL6399255 | 0.77 | CNR2 (0.31) | — | |
| SCHEMBL6399685 | 0.77 | ELANE (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578736-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-09-28 | — | — | EP | claimed |
| US-20050004186-A1 | MEK inhibiting compounds | PFIZER INC | 2005-01-06 | — | — | US | claimed |
| WO-2004056789-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | claimed |
| US-20050004186-A1 | MEK inhibiting compounds | PFIZER INC | 2005-01-06 | — | — | US | disclosed |