Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079114 | 0.95 | SMN1; SMN2 (0.43) | SMN1; SMN2MRGPRX4KDM4EALDH1A1MEN1 | |
| SCHEMBL6206439 | 0.77 | GABRA1 (0.44) | SMN1; SMN2KMT2ASGMS2 | |
| SCHEMBL6206177 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM4EALDH1A1KMT2ASGMS2 | |
| SCHEMBL30723732 | 0.71 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM4EALDH1A1KMT2ASGMS2 | |
| SCHEMBL6203080 | 0.69 | KDM4E (0.41) | SMN1; SMN2KDM4EALDH1A1GAASGMS2 | |
| SCHEMBL6238555 | 0.69 | SMN1; SMN2 (0.45) | SMN1; SMN2KDM4EALDH1A1KMT2AMET | |
| SCHEMBL27333081 | 0.68 | KMT2A (0.37) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL30723605 | 0.68 | KMT2A (0.37) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6238556 | 0.68 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1MEN1KMT2ASGMS2 | |
| SCHEMBL110369 | 0.67 | AKR1B1 (0.52) | SMN1; SMN2ALDH1A1MEN1KMT2AAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545523-A1 | 3-&-grave;(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES ASP38 MAP KINASE INHIBITORS | Astex Technology Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004004720-A1 | 3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |