Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6238556 | 0.80 | SMN1; SMN2 (0.44) | ALDH1A1POLBSMN1; SMN2PKMCYP1A2 | |
| SCHEMBL6205919 | 0.80 | ALDH1A1 (0.44) | KDM4EALDH1A1POLBSMN1; SMN2PKM | |
| SCHEMBL6078486 | 0.73 | SMN1; SMN2 (0.41) | POLBGAASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL30723732 | 0.72 | SMN1; SMN2 (0.47) | KDM4EALDH1A1SMN1; SMN2PKMMET | |
| SCHEMBL6206177 | 0.72 | SMN1; SMN2 (0.47) | KDM4EALDH1A1SMN1; SMN2PKMTDP1 | |
| SCHEMBL6202806 | 0.72 | PLK1 (0.40) | POLBSMN1; SMN2 | |
| SCHEMBL6079114 | 0.70 | SMN1; SMN2 (0.43) | KDM4EALDH1A1GAASMN1; SMN2TP53 | |
| SCHEMBL6206439 | 0.70 | GABRA1 (0.44) | POLBSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6238555 | 0.70 | SMN1; SMN2 (0.45) | KDM4EALDH1A1SMN1; SMN2PKMMET | |
| SCHEMBL6206853 | 0.69 | SMN1; SMN2 (0.39) | KDM4EALDH1A1GAASMN1; SMN2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545523-A1 | 3-&-grave;(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES ASP38 MAP KINASE INHIBITORS | Astex Technology Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2005002673-A1 | RAF KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |
| WO-2004004720-A1 | 3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |