Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.37 |
| ▸ | BRAF | P15056 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 3/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079684 | 0.81 | MAPK13 (0.60) | MAPK14BRAFMAPK13MAPK12MAPK11 | |
| SCHEMBL6078849 | 0.80 | BRAF (0.48) | BRAF | |
| SCHEMBL6079909 | 0.78 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11FLT3 | |
| SCHEMBL6233788 | 0.78 | FLT3 (0.53) | MAPK14BRAFMAPK13MAPK12MAPK11 | |
| SCHEMBL6079289 | 0.78 | MAPK14 (0.59) | MAPK14BRAFMAPK13MAPK12MAPK11 | |
| SCHEMBL6079268 | 0.77 | KCNJ6 (0.52) | BRAFKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL6080298 | 0.77 | MAPK14 (0.56) | MAPK14BRAFMAPK13MAPK12MAPK11 | |
| SCHEMBL6079886 | 0.76 | RAB9A (0.51) | NPC1MAPT | |
| SCHEMBL6079633 | 0.76 | KCNJ6 (0.64) | NTRK1KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL6078855 | 0.76 | BRAF (0.54) | MAPK14BRAFMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545523-A1 | 3-&-grave;(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES ASP38 MAP KINASE INHIBITORS | Astex Technology Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004004720-A1 | 3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |