Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203472 | 0.86 | ALOX5 (0.34) | — | |
| SCHEMBL6206927 | 0.71 | HPGD (0.37) | NAMPTTP53HPGDCYP1A2GAA | |
| SCHEMBL6872594 | 0.69 | — | — | |
| SCHEMBL13402884 | 0.63 | TP53 (0.38) | NAMPTTP53HPGDCYP1A2GAA | |
| SCHEMBL1006489 | 0.63 | NAMPT (0.54) | NAMPTTP53HPGDGAAPDK2 | |
| SCHEMBL6371222 | 0.62 | TP53 (0.53) | NAMPTTP53HPGDCYP1A2GAA | |
| SCHEMBL3854271 | 0.62 | HCAR3 (0.44) | NAMPTPDK2ALDH1A1ACACB | |
| SCHEMBL21077963 | 0.62 | CDK4 (0.50) | NAMPTPDK2ALDH1A1ACACBEGFR | |
| SCHEMBL4495603 | 0.62 | ESRRG (0.56) | NAMPTTSHRPDK2ALDH1A1ACACB | |
| SCHEMBL12620403 | 0.61 | HPGD (0.46) | TP53HPGDTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532132-A1 | NOVEL BENZODIOXOLES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004013120-A1 | NOVEL BENZODIOXOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-02-12 | — | — | WO | disclosed |