Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 7/20 | 0.55 |
| ▸ | CES2 | O00748 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206587 | 0.86 | CES2 (0.58) | CES1CES2MAPTL3MBTL1CYP3A4 | |
| SCHEMBL433480 | 0.82 | MAPT (0.56) | CES1CES2MAPTL3MBTL1CYP3A4 | |
| SCHEMBL16942397 | 0.77 | MEN1 (0.60) | MAPTTDP1TSHRHSD17B10SMN1; SMN2 | |
| SCHEMBL6666603 | 0.77 | CES1 (0.48) | CES1CES2MAPTL3MBTL1CYP3A4 | |
| SCHEMBL6206988 | 0.74 | CES1 (0.55) | CES1CES2MAPTL3MBTL1CYP3A4 | |
| SCHEMBL16796028 | 0.73 | CYP2C19 (0.46) | CES1CES2MAPTL3MBTL1CYP3A4 | |
| SCHEMBL7310816 | 0.73 | MEN1 (0.63) | MAPTTDP1TSHRHSD17B10SMN1; SMN2 | |
| SCHEMBL8515211 | 0.72 | CES1 (0.52) | CES1CES2MAPTL3MBTL1CYP3A4 | |
| SCHEMBL7669290 | 0.71 | CES2 (1.00) | CES1CES2MAPTL3MBTL1NPSR1 | |
| SCHEMBL4625390 | 0.71 | CES2 (1.00) | CES1CES2MAPTL3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |