Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14950848 | 0.61 | SMN1; SMN2 (0.34) | KMT2AMEN1TSHRGAASMN1; SMN2 | |
| SCHEMBL3322492 | 0.60 | HTT (0.33) | KMT2AMEN1USP2SMN1; SMN2NPC1 | |
| SCHEMBL11456012 | 0.59 | CHRM3 (0.35) | KMT2AMEN1USP2SMN1; SMN2NPC1 | |
| SCHEMBL13035732 | 0.59 | POLB (0.60) | KMT2ATSHRUSP2GAANPSR1 | |
| Ammonia Solution, Strong SCHEMBL8123114 | 0.58 | POLB (0.59) | KMT2ATSHRUSP2GAANPSR1 | |
| SCHEMBL14824638 | 0.58 | KMT2A (0.38) | KMT2AMEN1USP2GAAKDM4E | |
| SCHEMBL20129685 | 0.57 | DRD2 (0.64) | KMT2AMEN1USP2GAANPC1 | |
| SCHEMBL2093867 | 0.57 | MAPT (0.41) | KMT2AMEN1TSHRGAANPSR1 | |
| SCHEMBL412859 | 0.57 | TSHR (0.38) | KMT2AMEN1TSHRUSP2GAA | |
| SCHEMBL11842500 | 0.57 | USP2 (0.52) | KMT2AMEN1PKMTSHRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562595-A1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004026305-A1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONIST | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |