Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768389 | 0.83 | FLT3 (0.49) | FLT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL20425436 | 0.79 | ALDH1A1 (0.47) | FLT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5776749 | 0.79 | FLT3 (0.46) | FLT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL10472895 | 0.78 | FLT3 (0.50) | FLT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL16595609 | 0.77 | FLT3 (0.49) | FLT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL20425403 | 0.76 | MAOB (0.44) | FLT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8036000 | 0.75 | KDM4E (0.46) | FLT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL800706 | 0.75 | KDM4E (0.44) | FLT3RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28018770 | 0.74 | KDM4E (0.44) | FLT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL10480336 | 0.74 | FLT3 (0.46) | FLT3NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313736-B1 | CONDENSED PYRAZINDIONE DERIVATIVES AS INHIBITORS OF PDE5 | LILLY ICOS LLC (US) | 2005-07-27 | — | — | EP | disclosed |
| US-6903099-B2 | Condensed pyrazindione derivatives | LILLY ICOS LLC (US) | 2005-06-07 | — | — | US | disclosed |
| US-20030181457-A1 | Chemical compounds | LILLY ICOS LLC | 2003-09-25 | — | — | US | disclosed |
| EP-1313736-A2 | CONDENSED PYRAZINDIONE DERIVATIVES | Lilly Icos LLC (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002000657-A2 | CONDENSED PYRAZINDIONE DERIVATIVES | LILLY ICOS LLC (US) | 2002-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181457-A1 | Chemical compounds | ABCG2, SDHA, CYP11B1 | FLT3 1004/4885NPC1 100/4885RAB9A 1805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.