SCHEMBL6207286

SCHEMBL6207286

C#Cc1ccc(Nc2c(-c3nnc(NCCN4CCOCC4)o3)ccc(F)c2F)c(F)c1.OCCCc1ccc(Nc2c(-c3nnc(NCCN4CCOCC4)o3)ccc(F)c2F)c(F)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 11/20 0.40
KCNH2 Q12809 10/20 0.40
MAP3K8 P41279 3/20 0.40
CHRNA1 P02708 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
CHRNB2 P17787 1/20 0.40
CYP2C19 P33261 1/20 0.40
CHRNA4 P43681 1/20 0.40
SIGMAR1 Q99720 1/20 0.36
CSF1R P07333 1/20 0.35
MAP2K1 Q02750 3/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
HSD17B10 Q99714 1/20 0.33
MAPK13 O15264 1/20 0.33
PRKD3 O94806 1/20 0.33
PRKCG P05129 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6190835 0.94 CHRNA7 (0.45) CHRNA7KCNH2MAP3K8CHRNA1CYP1A2
SCHEMBL6207282 0.91 MAP3K8 (0.46) CHRNA7KCNH2MAP3K8CHRNA1CYP1A2
SCHEMBL6190172 0.89 CHRNA7 (0.44) CHRNA7KCNH2MAP3K8CHRNA1CYP1A2
SCHEMBL6399220 0.83 CHRNA7 (0.43) CHRNA7KCNH2MAP3K8CHRNA1CYP1A2
SCHEMBL6403862 0.82 CHRNA7 (0.42) CHRNA7KCNH2MAP3K8CHRNA1CYP1A2
SCHEMBL6191826 0.82 MAP2K1 (0.38) CYP3A4MAP2K1
SCHEMBL6207586 0.82 MAP3K8 (0.42) CHRNA7KCNH2MAP3K8CHRNA1CYP1A2
SCHEMBL6189562 0.81 CHRNA7 (0.44) CHRNA7KCNH2MAP3K8CHRNA1CYP1A2
SCHEMBL6403620 0.80 CHRNA7 (0.48) CHRNA7KCNH2MAP3K8CHRNA1CYP1A2
SCHEMBL15598681 0.80 CHRNA7 (0.44) CHRNA7KCNH2MAP3K8CHRNA1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1578736-A1 MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES Warner-Lambert Company LLC (US) 2005-09-28 EP claimed
WO-2004056789-A1 MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES WARNER-LAMBERT COMPANY LLC (US) 2004-07-08 WO claimed