Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.72 |
| ▸ | CNR1 | P21554 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207332 | 1.00 | CNR2 (0.72) | CNR2CNR1ALDH1A1TDP1MAPK8 | |
| SCHEMBL6457547 | 0.88 | ALDH1A1 (0.63) | CNR2CNR1ALDH1A1TDP1MAPK8 | |
| SCHEMBL6457540 | 0.88 | ALDH1A1 (0.63) | CNR2CNR1ALDH1A1TDP1MAPK8 | |
| SCHEMBL2488803 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL6456808 | 0.82 | CNR2 (0.51) | CNR2CNR1ALDH1A1TDP1MAPK8 | |
| Hydrochloric Acid SCHEMBL6456818 | 0.82 | CNR2 (0.51) | CNR2CNR1ALDH1A1TDP1MAPK8 | |
| SCHEMBL317252 | 0.82 | ALDH1A1 (0.52) | CNR2CNR1ALDH1A1TDP1MAPK8 | |
| Hydrochloric Acid SCHEMBL6456783 | 0.81 | CNR2 (0.49) | CNR2CNR1ALDH1A1TDP1MAPK8 | |
| Hydrochloric Acid SCHEMBL6456772 | 0.81 | CNR2 (0.49) | CNR2CNR1ALDH1A1TDP1MAPK8 | |
| SCHEMBL315480 | 0.80 | ALDH1A1 (0.50) | CNR2CNR1ALDH1A1TDP1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1595871-A2 | Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases | NPS PHARMACEUTICALS, INC. (US) | 2005-11-16 | — | — | EP | disclosed |