Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | CNR2 | P34972 | 3/20 | 0.56 |
| ▸ | CNR1 | P21554 | 2/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | F10 | P00742 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6457547 | 1.00 | ALDH1A1 (0.63) | ALDH1A1CNR2CNR1MAPK8TDP1 | |
| SCHEMBL8352785 | 0.90 | CNR1 (0.59) | ALDH1A1CNR2CNR1KMT2AF2 | |
| SCHEMBL8351097 | 0.90 | CNR1 (0.59) | ALDH1A1CNR2CNR1KMT2AF2 | |
| Hydrochloric Acid SCHEMBL6063567 | 0.89 | CNR1 (0.58) | ALDH1A1CNR2CNR1KMT2AF2 | |
| SCHEMBL6207330 | 0.88 | CNR2 (0.72) | ALDH1A1CNR2CNR1MAPK8TDP1 | |
| SCHEMBL6207332 | 0.88 | CNR2 (0.72) | ALDH1A1CNR2CNR1MAPK8TDP1 | |
| SCHEMBL8319888 | 0.84 | RAB9A (0.47) | ALDH1A1CNR2CNR1KMT2AF2 | |
| Hydrochloric Acid SCHEMBL5751698 | 0.83 | RAB9A (0.46) | ALDH1A1CNR2CNR1KMT2AF2 | |
| Hydrochloric Acid SCHEMBL5751702 | 0.83 | RAB9A (0.46) | ALDH1A1CNR2CNR1KMT2AF2 | |
| Hydrochloric Acid SCHEMBL6063508 | 0.81 | PDE4A (0.51) | ALDH1A1CNR2CNR1KMT2AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | ALDH1A1 2036/4885CNR2 52/4885CNR1 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.