Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27827222 | 0.86 | NFE2L2 (0.33) | NFE2L2 | |
| SCHEMBL27827263 | 0.85 | NFE2L2 (0.34) | NFE2L2 | |
| SCHEMBL3464112 | 0.85 | NFE2L2 (0.35) | NFE2L2 | |
| SCHEMBL3465609 | 0.82 | NFE2L2 (0.33) | NFE2L2KDM4E | |
| SCHEMBL27845941 | 0.81 | NFE2L2 (0.32) | NFE2L2 | |
| SCHEMBL27827248 | 0.81 | NFE2L2 (0.32) | NFE2L2 | |
| SCHEMBL3126398 | 0.79 | PIK3C3 (0.34) | NFE2L2 | |
| SCHEMBL10920036 | 0.78 | ROCK1 (0.40) | PTGS2 | |
| SCHEMBL3465567 | 0.77 | ALDH1A1 (0.32) | NFE2L2ALDH1A1 | |
| SCHEMBL3466038 | 0.76 | KDM4D (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |