Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6208071 | 0.83 | AKR1C1 (0.44) | POLBSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL2809048 | 0.83 | SMN1; SMN2 (0.47) | POLBSMN1; SMN2KMT2AALDH1A1NPC1 | |
| SCHEMBL2809046 | 0.83 | SMN1; SMN2 (0.47) | POLBSMN1; SMN2KMT2AALDH1A1NPC1 | |
| SCHEMBL6206194 | 0.81 | L3MBTL1 (0.43) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL6206649 | 0.80 | AKR1C1 (0.44) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL6206216 | 0.80 | AKR1C1 (0.44) | POLBSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL6187374 | 0.80 | AKR1C1 (0.47) | POLBSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL1996920 | 0.78 | AKR1C1 (0.53) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL2407093 | 0.78 | AKR1C1 (0.53) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL1996915 | 0.78 | AKR1C1 (0.53) | POLBKMT2AMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |