Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207378 | 0.83 | POLB (0.49) | AKR1C1KMT2AALDH1A1NPSR1MAPT | |
| SCHEMBL2811159 | 0.83 | AKR1C3 (0.44) | RXRARXRBRXRGALDH1A1NPSR1 | |
| SCHEMBL2811157 | 0.83 | AKR1C3 (0.44) | RXRARXRBRXRGALDH1A1NPSR1 | |
| SCHEMBL6206194 | 0.81 | L3MBTL1 (0.43) | AKR1C1KMT2AALDH1A1NPSR1MAPT | |
| SCHEMBL6206649 | 0.80 | AKR1C1 (0.44) | AKR1C1KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL6206216 | 0.80 | AKR1C1 (0.44) | AKR1C1KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL6187374 | 0.80 | AKR1C1 (0.47) | AKR1C1KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL13787621 | 0.79 | RXRA (0.39) | RXRARXRBRXRGKMT2AALDH1A1 | |
| SCHEMBL19640358 | 0.77 | AKR1C1 (0.52) | AKR1C1KMT2AALDH1A1MEN1AKR1C2 | |
| SCHEMBL6205776 | 0.76 | ALDH1A1 (0.55) | KMT2AALDH1A1MAPTMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |