Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21047728 | 0.76 | KMT2A (0.36) | MEN1KMT2AKDM4EMAPTTDP1 | |
| SCHEMBL3837450 | 0.68 | SLC6A2 (0.62) | SLC6A4SLC6A2SLC18A3SIGMAR1HRH1 | |
| SCHEMBL4558469 | 0.67 | HTR1A (0.36) | CHRM5CHRM3CHRM1CHRM2CHRM4 | |
| SCHEMBL8372303 | 0.67 | CHRM5 (0.52) | CHRM5CHRM3CHRM1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL18263847 | 0.67 | SLC6A2 (0.60) | SLC6A4SLC6A2SLC18A3SIGMAR1HRH1 | |
| SCHEMBL9934196 | 0.63 | HTR2C (0.44) | SLC18A3SIGMAR1HTR2C | |
| SCHEMBL6534546 | 0.63 | ADORA2A (0.42) | SLC6A4SLC6A2CHRM5CHRM3CHRM1 | |
| SCHEMBL31370607 | 0.63 | GBA1 (0.52) | SLC6A4CHRM5CHRM3CHRM1CHRM2 | |
| SCHEMBL1477408 | 0.62 | TP53 (0.41) | MEN1LMNAKMT2ANISCHKDM4E | |
| SCHEMBL25389560 | 0.62 | TACR1 (0.50) | SLC6A4SLC6A2SIGMAR1SLC6A3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534703-A2 | ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR | ABBOTT LABORATORIES (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2003106452-A2 | ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-12-24 | — | — | WO | disclosed |