Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3248430 | 0.74 | ALDH1A1 (0.50) | MAPTATMALDH1A1CA1CA2 | |
| SCHEMBL3248426 | 0.74 | ALDH1A1 (0.50) | MAPTATMALDH1A1CA1CA2 | |
| SCHEMBL11721311 | 0.68 | RAB9A (0.68) | MAPTALDH1A1ALOX15NPC1RAB9A | |
| SCHEMBL1507665 | 0.67 | CA1 (0.54) | MAPTTHRBATMALDH1A1ALOX15 | |
| SCHEMBL21501142 | 0.67 | CA1 (0.48) | MAPTALDH1A1ALOX15LMNAAPEX1 | |
| SCHEMBL7358417 | 0.66 | MAPT (0.53) | MAPTALDH1A1ALOX15LMNAAPEX1 | |
| SCHEMBL2795435 | 0.66 | CYP2C9 (0.55) | MAPTALDH1A1ALOX15LMNAAPEX1 | |
| SCHEMBL4232572 | 0.66 | CA1 (0.52) | MAPTTHRBATMALDH1A1ALOX15 | |
| SCHEMBL20986637 | 0.66 | KCNN4 (0.39) | MAPTALDH1A1ALOX15MAPK1HSD17B10 | |
| SCHEMBL1939457 | 0.66 | AKR1C3 (0.54) | MAPTALDH1A1ALOX15LMNAAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583749-A1 | OXAZOLE DERIVATIVES AS INHIBITORS OF CYCLOOXYGENASE | Astellas Pharma Inc. (JP) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004065374-A1 | OXAZOLE DERIVATIVES AS INHIBITORS OF CYCLOOXYGENASE | ASTELLAS PHARMA INC. (JP) | 2004-08-05 | — | — | WO | disclosed |