Sugi Predict

Sugi Predict / Compounds / SCHEMBL6207563

SCHEMBL6207563

SCHEMBL6207563

Nc1nc(SCc2ccccc2)n[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ RECQL P46063 1/20 0.71
▸ RAB9A P51151 5/20 0.66
▸ SMN1; SMN2 Q16637 4/20 0.60
▸ LMNA P02545 2/20 0.60
▸ METAP2 P50579 3/20 0.59
▸ METAP1 P53582 1/20 0.59
▸ GLA P06280 1/20 0.58
▸ ROCK2 O75116 1/20 0.57
▸ MAP4K4 O95819 1/20 0.57
▸ PRKX P51817 1/20 0.57
▸ AURKB Q96GD4 1/20 0.57
▸ CLK4 Q9HAZ1 1/20 0.57
▸ SGK2 Q9HBY8 1/20 0.57
▸ MAP4K5 Q9Y4K4 1/20 0.57
▸ NPC1 O15118 1/20 0.57
▸ TP53 P04637 1/20 0.56
▸ HPGD P15428 1/20 0.55
▸ ALOX15 P16050 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16341398 0.85 GRIN2B (0.57) RECQLSMN1; SMN2LMNAGLAHPGD
SCHEMBL28640848 0.83 RECQL (1.00) RECQLRAB9ASMN1; SMN2LMNAMETAP2
SCHEMBL28631726 0.83 RECQL (0.72) RECQLRAB9ASMN1; SMN2LMNANPC1
SCHEMBL14027548 0.83 RECQL (0.72) RECQLRAB9ASMN1; SMN2LMNAMETAP2
SCHEMBL14027549 0.82 SMN1; SMN2 (0.63) RECQLSMN1; SMN2LMNAMETAP2TP53
SCHEMBL10560421 0.81 RAB9A (0.68) RAB9ASMN1; SMN2METAP2METAP1ROCK2
SCHEMBL10561244 0.79 RAB9A (0.66) RECQLRAB9ASMN1; SMN2METAP2METAP1
SCHEMBL28629734 0.78 NPC1 (0.57) RECQLRAB9ASMN1; SMN2LMNAMETAP2
SCHEMBL14049993 0.78 RECQL (0.53) RECQLRAB9ASMN1; SMN2LMNATP53
SCHEMBL14027543 0.78 SMN1; SMN2 (0.71) RECQLSMN1; SMN2LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110615792-B 2-benzylthio-5-methyl-4, 7-dihydro- [1,2,4] triazolo [1,5-a ] pyrimidine derivatives HEBEI UNIVERSITY OF TECHNOLOGY (CN) 2021-08-31 — — CN claimed
CN-110615792-A 2-benzylthio-5-methyl-4, 7-dihydro- [1,2,4] triazolo [1,5-a ] pyrimidine derivatives 河北工业大学 2019-12-27 — — CN claimed
CN-110615792-B 2-benzylthio-5-methyl-4, 7-dihydro- [1,2,4] triazolo [1,5-a ] pyrimidine derivatives HEBEI UNIVERSITY OF TECHNOLOGY (CN) 2021-08-31 — — CN disclosed
CN-110679602-B Application of alkaloid esramycin and derivatives thereof in resisting plant viruses 河北工业大学 2021-05-18 — — CN disclosed
CN-110679602-A Application of alkaloid esramycin and derivatives thereof in resisting plant viruses 河北工业大学 2020-01-14 — — CN disclosed
CN-110615792-A 2-benzylthio-5-methyl-4, 7-dihydro- [1,2,4] triazolo [1,5-a ] pyrimidine derivatives 河北工业大学 2019-12-27 — — CN disclosed
CN-105555785-B 2, 3-dihydrobenzofuran-5-yl compounds as DYRK kinase inhibitors 4SC股份公司 2019-03-01 — — CN disclosed
US-10005769-B2 2,3-dihydrobenzofuran-5YL compounds as DYRK kinase inhibitors 4SC AG (DE) 2018-06-26 — — US disclosed
US-20160137637-A1 2,3-DIHYDROBENZOFURAN-5YL COMPOUNDS AS DYRK KINASE INHIBITORS 4SC DISCOVERY GMBH (DE) 2016-05-19 — — US disclosed
CN-105555785-A 2,3-dihydrobenzofuran-5-yl compounds as DYRK kinase inhibitors 4SC DISCOVERY GMBH 2016-05-04 — — CN disclosed
EP-3010920-A1 2,3-DIHYDROBENZOFURAN-5-YL COMPOUNDS AS DYRK KINASE INHIBITORS 4SC Discovery GmbH (DE) 2016-04-27 — — EP disclosed
WO-2004046149-A1 2-MERCAPTO-SUBSTITUTED TRIAZOLOPYRIMIDINES, METHODS FOR THE PRODUCTION THEREOF, THE USE OF THE SAME FOR CONTROLLING PATHOGENIC FUNGI, AND AGENTS CONTAINING SAID COMPOUNDS BASF AKTIENGESELLSCHAFT (DE) 2004-06-03 — — WO disclosed
EP-0272628-B1 6,7-Dihydro-[1,2,4]triazolo[1,5-a][1,3,5]triazine-2-sulfonamides, process for their preparation and their use as agents with a herbicidal and growth-regulating activity SCHERING AKTIENGESELLSCHAFT (DE) 1992-04-29 — — EP disclosed
US-4889553-A Herbicides SCHERING AGROCHEMICALS (GB) 1989-12-26 — — US disclosed
US-4859231-A (6,7-)dihydro-(1,2,4) triazolo (1,5-A) (1,3,5) Triazine-2-sulphonamides, and their use as herbicides and plant growth regulators SCHERING AKTIENGESELLSCHAFT (DE) 1989-08-22 — — US disclosed
US-4854964-A Triazolo-pyrimidine-2-sulphonamides having herbicidal utility BAYER AKTIENGESELLSCHAFT (DE) 1989-08-08 — — US disclosed
EP-0272628-A2 6,7-Dihydro-[1,2,4]triazolo[1,5-a][1,3,5]triazine-2-sulfonamides, process for their preparation and their use as agents with a herbicidal and growth-regulating activity SCHERING AKTIENGESELLSCHAFT (DE) 1988-06-29 — — EP disclosed
EP-0256396-A1 Triazolo-pyrimidine-2-sulfon amides BAYER AG (DE) 1988-02-24 — — EP disclosed
CN-87103542-A Herbicide — 1988-02-03 — — CN disclosed
EP-0246749-A2 Triazole herbicides AgrEvo UK Limited (GB) 1987-11-25 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10005769-B2 2,3-dihydrobenzofuran-5YL compounds as DYRK kinase inhibitors DYRK2, DYRK1B, DYRK1A RECQL 755/4885RAB9A 1851/4885SMN1; SMN2 3903/4885
US-20160137637-A1 2,3-DIHYDROBENZOFURAN-5YL COMPOUNDS AS DYRK KINASE INHIBITORS DYRK2, DYRK1B, DYRK1A RECQL 755/4885RAB9A 1851/4885SMN1; SMN2 3903/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.