SCHEMBL6207782

SCHEMBL6207782

OCCCCc1ncco1

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 2/20 0.36
FAAH O00519 1/20 0.34
CES1 P23141 1/20 0.34
NCEH1 Q6PIU2 1/20 0.34
KDM4E B2RXH2 1/20 0.34
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC10 Q969S8 1/20 0.33
HDAC11 Q96DB2 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
HDAC9 Q9UKV0 1/20 0.33
HDAC5 Q9UQL6 1/20 0.33
SIRT2 Q8IXJ6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9596022 0.98 TLR7 (0.37) TLR7FAAHCES1NCEH1KDM4E
SCHEMBL21646062 0.98 TLR7 (0.37) TLR7FAAHCES1NCEH1KDM4E
SCHEMBL1495178 0.94
SCHEMBL7027055 0.87 FAAH (0.38) FAAHCES1NCEH1HDAC3HDAC4
SCHEMBL7022926 0.87 FAAH (0.38) FAAHCES1NCEH1HDAC3HDAC4
SCHEMBL7029638 0.87 FAAH (0.38) FAAHCES1NCEH1HDAC3HDAC4
SCHEMBL1646782 0.85
Oxazole SCHEMBL27444049 0.81
SCHEMBL29086344 0.79 CYP1B1 (0.32) FAAHCES1NCEH1
SCHEMBL8569658 0.79 HRH1 (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1515726-A1 MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS Aventis Pharmaceuticals, Inc. (US) 2005-03-23 EP disclosed
EP-1383748-A2 NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-01-28 EP disclosed
WO-2004002491-A1 MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2004-01-08 WO disclosed
WO-2002051983-A2 NOVEL COMPOUNDS AND COMPOSITIONS AS CATHEPSIN INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-07-04 WO disclosed