Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 12/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | HRH2 | P25021 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504566 | 0.98 | HRH1 (0.43) | HRH1HRH3HRH4HRH2 | |
| SCHEMBL11005395 | 0.94 | — | — | |
| SCHEMBL7022926 | 0.87 | FAAH (0.38) | — | |
| SCHEMBL7029638 | 0.87 | FAAH (0.38) | — | |
| SCHEMBL7027055 | 0.87 | FAAH (0.38) | — | |
| SCHEMBL659550 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL14743990 | 0.83 | HRH1 (0.34) | HRH1HRH2 | |
| SCHEMBL29086344 | 0.79 | CYP1B1 (0.32) | — | |
| SCHEMBL6207782 | 0.79 | TLR7 (0.36) | — | |
| SCHEMBL859772 | 0.79 | FAAH (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821675-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033176-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-10-24 | — | — | WO | disclosed |
| US-4656176-A | 2-thiazolyl, oxazolyl, triazolyl and thiadiazolyl alkylamino-3-nitro-heterocyclic compounds | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-04-07 | — | — | US | disclosed |
| US-4525477-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-06-25 | — | — | US | disclosed |