Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 2/20 | 0.31 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6433614 | 0.80 | CA1 (0.40) | CA1CA2CA9LDHAHSD11B1 | |
| SCHEMBL5955867 | 0.76 | CA1 (0.33) | CA1CA2CA9LDHAHSD11B1 | |
| SCHEMBL17898050 | 0.73 | PIK3CG (0.36) | CA1CA2CA9LDHAHSD11B1 | |
| SCHEMBL27365749 | 0.71 | AKR1C4 (0.42) | HSD11B1POLBCASP3SENP7SENP6 | |
| SCHEMBL5955871 | 0.70 | DPP4 (0.37) | CA1CA2CA9DPP4DPP8 | |
| SCHEMBL17897216 | 0.69 | FABP4 (0.36) | CA1CA2CA9HSD11B1POLB | |
| SCHEMBL5516375 | 0.68 | SMN1; SMN2 (0.32) | CA1CA2CA9HSD11B1POLB | |
| SCHEMBL5516368 | 0.68 | SMN1; SMN2 (0.32) | CA1CA2CA9HSD11B1POLB | |
| SCHEMBL14427060 | 0.65 | FABP4 (0.33) | LDHAHSD11B1POLBFABP4FABP5 | |
| SCHEMBL14110444 | 0.64 | CPT1A (0.37) | LDHAHSD11B1POLBAKR1C4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515726-A1 | MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2005-03-23 | — | — | EP | claimed |
| WO-2004002491-A1 | MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2004-01-08 | — | — | WO | claimed |